What is Ovarian Rejuvenation therapy?

Ovarian Rejuvenation is a modern regenerative treatment designed to help women restore ovarian activity and improve egg quality using their own biological material — typically Platelet-Rich Plasma (PRP) or Exosomes.

Who is the therapy suitable for?

It’s recommended for women with low ovarian reserve, early menopause, diminished AMH levels, or those who haven’t responded well to previous IVF stimulation.

How does the procedure work?

The process involves taking a small sample of your own blood, isolating growth factors or exosomes, and gently injecting them into the ovaries under ultrasound guidance. These biologically active substances stimulate tissue regeneration and follicle activation.

Yes. Since the material comes from your own body, there’s no risk of rejection or allergy. The procedure is minimally invasive and performed under light anesthesia by experienced reproductive specialists.

How long does the procedure take?

The entire process takes around 30–40 minutes, including preparation and recovery. Most patients return to normal activities the same day.

What results can I expect?

Many patients experience improved ovarian function within 2–3 months. This may include increased AMH levels, the return of menstruation, or the ability to produce mature eggs for IVF. Results vary individually.

Can it help me get pregnant naturally?

In some cases, yes. Restored ovarian activity can lead to spontaneous ovulation and natural conception, but results depend on age and baseline ovarian function.

How soon can I start IVF after the procedure?

Typically within 6–8 weeks, once hormone levels and ultrasound indicators show ovarian response. Your IFG fertility specialist will guide the exact timeline.

What’s the difference between PRP and Exosome therapy?

PRP uses your own blood plasma with concentrated growth factors, while Exosome therapy delivers even smaller bioactive particles that enhance cell regeneration. Exosomes are often more potent for cellular repair.

Is Ovarian Rejuvenation painful?

The procedure is performed under anesthesia and is usually well tolerated. Mild discomfort or spotting may occur for a day or two afterward.

How many treatments are needed?

Usually one session is enough, but in some cases a follow-up may be advised after 6 months depending on ovarian response.

Are there any risks or side effects?

Side effects are minimal. Temporary pelvic discomfort or mild cramping may occur. As it’s autologous (your own material), infection or allergic reactions are extremely rare.

Can I combine Ovarian Rejuvenation with IVF or Egg Donation

Absolutely. It can be performed before IVF to improve egg quality or as preparation before using donor eggs — enhancing endometrial and ovarian receptivity.

Where can I do the procedure?

IFG offers Ovarian Rejuvenation programs through its partner clinics in Georgia, Slovakia, Albania, and Ukraine, ensuring full medical and logistic support.

Who performs the treatment?

The procedure is carried out by certified reproductive specialists under the supervision of Dr. Uliana Dorofeyeva and Dr. Birol Aydin, IFG’s leading experts in regenerative reproductive medicine.

Mitochondrial
Replacement
Therapy

Calculate your chances Start my journey

What is Mitochondrial Replacement Therapy (MRT)

MRT energizes your eggs by replacing compromised power sources with healthy donor mitochondria, while still preserving your own DNA. This approach targets egg quality issues that often lead to repeated IVF failures.

There are two techniques for MRT

Pronuclear Transfer (PNT) and Maternal Spindle Transfer (MST). Our medical support team will discuss your unique needs and which of these techniques will serve you best.

Pronuclear Transfer (PNT)

Pronuclear Transfer (PNT) and Maternal Spindle Transfer (MST).
Our medical support team will discuss your unique needs and which of these techniques will serve you best.

The nucleus from a fertilized egg containing unhealthy mitochondria is transferred into a donor egg with healthy mitochondria.
The donor egg’s nucleus is removed before the transfer, ensuring that only the intended parents’ DNA is passed on.
This process results in an embryo that carries the parents’ genetic material but benefits from optimal mitochondria, increasing the chances of a successful pregnancy.

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Maternal Spindle Transfer (MST)

Pronuclear Transfer (PNT) and Maternal Spindle Transfer (MST). Our medical support
team will discuss your unique needs and which of these techniques will serve you best.

The nucleus from the mother’s egg is removed and placed into a donor egg with healthy mitochondria.
This technique ensures that the embryo retains the mother’s genetic material while being powered by strong, functional mitochondria from the donor egg.
MST is particularly beneficial for women whose egg quality has been compromised due to age or mitochondrial disorders.

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Why MRT can transform your fertility journey

Keep your DNA
Your child carries your genes, not the donor’s.
Boost Egg Vitality
Healthy donor mitochondria can overcome egg-quality challenges.
Lower Inherited Risks
Replacing compromised mitochondria may reduce certain disorders.
A Possible Last Resort
Renew hope when standard IVF no longer seems to work.

Key statistics that inspire hope

Below are brief facts and figures about our MRT program. They may offer reassurance when you have gone through multiple IVF cycles.

As of February 2025, 34 babies have been born through MRT, with families from 32 countries.
The oldest MRT child is now over 7 years old.
Most MRT patients are between the ages of 39 and 52 when egg quality becomes a common concern.
A 48-year-old patient carried and delivered her baby through MRT.
Several patients over 50 are accumulating zygotes, proving it is never too late to try.
Many MRT patients are 42 to 46 and wish to keep their genetic connection.
We typically begin MRT with 4–6 eggs or embryos. Patients who produce fewer eggs (1–4) may benefit from our MINI program, while those able to bank more (4–15) are eligible for our full program.

We’ll take a close look at your hormone levels, cycle history, and goals to see if this could be the right next step for you.

Your journey matters to us

96+
Fertilization rate
66%
Blastulation rate
65%
Euploid blastocyst rate
54%
Clinical pregnancy rate
overall, 84% with surrogacy

The MRT Process in nine steps

MRT gently guides you from your first consultation to embryo transfer. Each phase offers support and guidance, helping you feel confident at every turn.

1
Consultation
We review your medical and IVF history to see if MRT is the right choice.
2
We review your medical and IVF history to see if MRT is the right choice.
Improve egg quality and potentially reduce retrieval cycles with our rejuvenation options.
3
Egg Retrieval
Your eggs are safely and gently retrieved in preparation for MRT.
4
Fertilization
We typically use Pronuclear Transfer at the zygote stage for greater precision and safety.
5
Shipping
Shipping to Tirana, Albania, if the retrievals and zygote creation happened abroad.
6
Mitochondrial Replacement
In our top-notch lab, experts delicately restore your egg’s energy by replacing weakened mitochondria and preserving your DNA.
7
Embryo Transfer
Before the fertilized embryo is placed in your uterus, genetic testing is performed to ensure the embryos have the best chance for a successful pregnancy, giving you renewed hope for a healthy outcome.
8
Pregnancy
We'll support you throughout your pregnancy, providing guidance and attentive monitoring for your health and your baby's development.
9
Welcome Your New Family Member
Celebrate the joyful arrival of your baby and begin your exciting new chapter with confidence and care from our dedicated team.

Request the program price list

Travel abroad and find new possibilities

Traveling for fertility treatment can feel overwhelming, yet it also opens doors to specialized care, a supportive environment, and the chance to explore a beautiful destination. Whether it’s the historic charm of Albania or the stunning coastlines nearby, this journey is not just about treatment—it’s about hope, renewal, and embracing a new chapter in your life.

Testimonials

“Amazing team! IFG supported us from day one and managed the entire journey with professionalism and heart. Clear communication, fast replies, and full guidance through the surrogacy process. We always felt safe and cared for. Would definitely recommend IFG to anyone looking for a reliable fertility agency.”

- Cindy Green

“Working with IFG made a complicated journey feel much easier. They handled the details, answered every question, and were always available when needed. It really felt like having a strong team supporting every step.”

- Markus

“From the very first call, I felt like I was in good hands. The IFG team explained everything clearly and stayed in touch the whole time. What could have been overwhelming actually felt organized and manageable thanks to them)”

- Erin Savitz

“I had an excellent experience with IFG. The entire team was incredibly supportive, informative, and caring throughout every step of the process. They made everything clear and stress-free, and I always felt that my case was handled with professionalism and compassion. Highly recommend their services!)”

- D S

“I’m honestly thankful to IFG for how they handled my whole journey. I didn’t know what to expect at first, but they were patient, answered every question, and guided me through things I had no idea about.
What I appreciated most is that I never felt pushed or judged. The coordinators were always in touch, even late evenings. It’s a stressful process, but with them it felt manageable. I’m really glad I chose IFG!)”

- Caroline Horner

“I had a wonderful experience with the International Fertility Group (IFG). They are thoroughly professional and will go all out to make your dream come true. Kesenia from IFG has really been an inspiration and she assured me and was an inspiration to the success. We were blessed with a beautiful baby boy whom we named Ian and it is all thanks to IFG and their team of highly professional individuals, doctors, laboratory personnel and other staff without them we would never have been parents.
I will highly recommend IFG to any potential parent. Ksenia is a wonderful coordinator and made us feel welcome and went through the process in a professional way. Even though I could not thank each of of the team, my heart goes out to them in saying a big THANK YOU.)”

- Winston Costa Pereira

“I truly appreciated how professional and attentive everyone at IFG was. Nothing felt rushed, and every stage was carefully coordinated. Having that level of support made all the difference.)”

- Kate Cummings

FAQ

What is Ovarian Rejuvenation therapy?
Who is the therapy suitable for?
How does the procedure work?
Is it safe?
How long does the procedure take?
What results can I expect?
Can it help me get pregnant naturally?
How soon can I start IVF after the procedure?
What’s the difference between PRP and Exosome therapy?
Is Ovarian Rejuvenation painful?
How many treatments are needed?
Are there any risks or side effects?
Can I combine Ovarian Rejuvenation with IVF or Egg Donation
Where can I do the procedure?
Who performs the treatment?

Start your journey now

We understand how emotional and complex this path can be. Our team will guide you through each step so you feel informed, supported, and hopeful about building your family.

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Mitochondrial Replacement Therapy